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Gastrointestinal tract carcinoma in pediatric and adolescent age: The Italian TREP project experience

Indini, Alice ; Bisogno, Gianni ; Cecchetto, Giovanni ; Vitellaro, Marco ; Signoroni, Stefano ; Massimino, Maura ; Riccipetitoni, Giovanna ; Zecca, Marco ; Dall' Igna, Patrizia ; De Pasquale, Maria Debora ; Inserra, Alessandro ; Chiaravalli, Stefano ; Basso, Eleonora ; Virgone, Calogero ; Sorbara, Silvia ; Bartolomeo, Maria ; D' Angelo, Paolo ; Ferrari, Andrea

Pediatric Blood & Cancer, December 2017, Vol.64(12), pp.n/a-n/a [Rivista Peer Reviewed]

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  • Titolo:
    Gastrointestinal tract carcinoma in pediatric and adolescent age: The Italian TREP project experience
  • Autore: Indini, Alice ; Bisogno, Gianni ; Cecchetto, Giovanni ; Vitellaro, Marco ; Signoroni, Stefano ; Massimino, Maura ; Riccipetitoni, Giovanna ; Zecca, Marco ; Dall' Igna, Patrizia ; De Pasquale, Maria Debora ; Inserra, Alessandro ; Chiaravalli, Stefano ; Basso, Eleonora ; Virgone, Calogero ; Sorbara, Silvia ; Bartolomeo, Maria ; D' Angelo, Paolo ; Ferrari, Andrea
  • Note di contenuto: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1002/pbc.26658/abstract Byline: Alice Indini, Gianni Bisogno, Giovanni Cecchetto, Marco Vitellaro, Stefano Signoroni, Maura Massimino, Giovanna Riccipetitoni, Marco Zecca,Patrizia Dall'Igna, Maria Debora De Pasquale, Alessandro Inserra, Stefano Chiaravalli, Eleonora Basso, Calogero Virgone, Silvia Sorbara, Maria Bartolomeo,Paolo D'Angelo,Andrea Ferrari Keywords: adenocarcinoma; colorectal cancer; children; rare pediatric tumors; TREP Abstract Background Gastrointestinal (GI) carcinomas are very rare in the pediatric and adolescent age range. We report the clinical features, treatment, and outcome of a series of children and adolescents with GI carcinoma prospectively registered in the Italian Tumori Rari in Eta Pediatrica (TREP) project. Methods The TREP project developed diagnostic and therapeutic guidelines based on recommendations currently in use for adults. Clinical data were centrally registered and reviewed. Results Fifteen patients were registered over the years 2000-2016. Most of the tumors were colorectal carcinomas (12 cases). All but one patient had advanced-stage disease (American Joint Committee on Cancer stages III-IV), and the majority of patients had aggressive histological subtypes, i.e. poorly differentiated (G3) (five patients), mucinous (four patients), and signet ring (two patients) adenocarcinomas. Surgery was performed in 13 of 15 patients, and was radical in nine of 13 patients. Only one patient received postoperative radiotherapy. All patients received chemotherapy, with the addition of bevacizumab in two cases. Nine patients were still alive at the time of the present report, but two of them had only just completed their treatment program and one patient is still on treatment. Six patients died due to disease progression. Conclusions This prospective report on pediatric GI tract carcinomas confirms the rarity and biological aggressiveness of these diseases in pediatric and adolescent age. Further prospective studies are needed to explore the distinct biology of tumor in this age group in order to find new therapeutic targeted agents. Article Note: Funding information Grant sponsor: "Fondazione Citta della Speranza," Padova; Grant sponsor: "Fondazione Cassa di Risparmio di Padova e Rovigo." CAPTION(S): Supplementary Table S1: Recent reports on colorectal carcinoma in children and adolescents Supplementary Table S2: Recent reports on gastric and small bowel carcinoma in children and adolescents
  • Fa parte di: Pediatric Blood & Cancer, December 2017, Vol.64(12), pp.n/a-n/a
  • Soggetti: Adenocarcinoma ; Colorectal Cancer ; Children ; Rare Pediatric Tumors ; Trep
  • Tipo: Articolo
  • Identificativo: ISSN: 1545-5009 ; E-ISSN: 1545-5017 ; DOI: 10.1002/pbc.26658

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