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Mature and immature teratoma: A report from the second Italian pediatric study

Terenziani, Monica ; D' Angelo, Paolo ; Inserra, Alessandro ; Boldrini, Renata ; Bisogno, Gianni ; Babbo, Gian Luca ; Conte, Massimo ; Dall' Igna, Patrizia ; De Pasquale, Maria Debora ; Indolfi, Paolo ; Piva, Luigi ; Riccipetitoni, Giovanna ; Siracusa, Fortunato ; Spreafico, Filippo ; Tamaro, Paolo ; Cecchetto, Giovanni

Pediatric Blood & Cancer, July 2015, Vol.62(7), pp.1202-1208 [Rivista Peer Reviewed]

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  • Titolo:
    Mature and immature teratoma: A report from the second Italian pediatric study
  • Autore: Terenziani, Monica ; D' Angelo, Paolo ; Inserra, Alessandro ; Boldrini, Renata ; Bisogno, Gianni ; Babbo, Gian Luca ; Conte, Massimo ; Dall' Igna, Patrizia ; De Pasquale, Maria Debora ; Indolfi, Paolo ; Piva, Luigi ; Riccipetitoni, Giovanna ; Siracusa, Fortunato ; Spreafico, Filippo ; Tamaro, Paolo ; Cecchetto, Giovanni
  • Note di contenuto: BACKGROUND: Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the first Italian study, we collected cases of teratoma, alongside the protocol for malignant germ cell tumors.PROCEDURE: Patients with teratoma were collected from 2004 to 2014. Teratomas were classified according to the WHO classifications, as mature and immature. Patients with pathological aFP and/or bHCG, and those with a malignant germ cell component were not included.RESULTS: The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primary sites involved were: 118 gonadal and 101 extragonadal teratomas. Two females with ovarian teratoma had a positive family history. Complete and incomplete surgeries were performed in 85% and 9% of cases. Seventeen events occurred: six females had a second metachronous tumor (5 contralateral ovarian teratoma, 1 adrenal neuroblastoma) and 11 teratomas relapsed/progressed (3 mature, 8 immature teratomas). Two patients died, one of progressive immature teratoma and one of surgical complications. At a median follow up of 68 months, the event-free, relapse-free, and overall survival rates were 90.6%, 94.3%, 98.6%, respectively.CONCLUSIONS: Teratomas show a good prognosis, especially the mature ones: surgery and follow-up remain the standard approach. Incomplete surgery in immature teratoma is the group at greatest risk of relapse. Bilateral ovarian tumors are a possibility, and the rare family predisposition to ovarian mature teratoma warrants further analyses.
  • Fa parte di: Pediatric Blood & Cancer, July 2015, Vol.62(7), pp.1202-1208
  • Soggetti: Childhood ; Germ Cell Tumors ; Immature Teratoma ; Mature Teratoma
  • Tipo: Articolo
  • Identificativo: ISSN: 1545-5009 ; E-ISSN: 1545-5017 ; DOI: 10.1002/pbc.25423

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