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Oncological outcomes of minimally invasive partial versus minimally invasive radical nephrectomy for cT1-2/N0/M0 clear cell renal cell carcinoma: a propensity score-matched analysis

Simone, Giuseppe ; Tuderti, Gabriele ; Anceschi, Umberto ; Papalia, Rocco ; Ferriero, Mariaconsiglia ; Misuraca, Leonardo ; Minisola, Francesco ; Mastroianni, Riccardo ; Costantini, Manuela ; Guaglianone, Salvatore ; Sentinelli, Steno ; Gallucci, Michele

World Journal of Urology, 2017, Vol.35(5), pp.789-794 [Rivista Peer Reviewed]

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  • Titolo:
    Oncological outcomes of minimally invasive partial versus minimally invasive radical nephrectomy for cT1-2/N0/M0 clear cell renal cell carcinoma: a propensity score-matched analysis
  • Autore: Simone, Giuseppe ; Tuderti, Gabriele ; Anceschi, Umberto ; Papalia, Rocco ; Ferriero, Mariaconsiglia ; Misuraca, Leonardo ; Minisola, Francesco ; Mastroianni, Riccardo ; Costantini, Manuela ; Guaglianone, Salvatore ; Sentinelli, Steno ; Gallucci, Michele
  • Note di contenuto: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00345-016-1923-2 Byline: Giuseppe Simone (1), Gabriele Tuderti (1), Umberto Anceschi (1), Rocco Papalia (1,2), Mariaconsiglia Ferriero (1), Leonardo Misuraca (1), Francesco Minisola (1), Riccardo Mastroianni (2), Manuela Costantini (1), Salvatore Guaglianone (1), Steno Sentinelli (3), Michele Gallucci (1) Keywords: Minimally invasive; Outcomes; Partial nephrectomy; Propensity score matching; Radical nephrectomy; Renal cell carcinoma Abstract: Purpose To compare the oncologic outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for cT1-2/N0 renal tumors and pathologically confirmed pT1-pT3a-pNx clear cell (cc)-renal cell carcinoma (RCC). Few studies compared the oncologic outcomes of PN and RN for renal tumors >7 cm. Methods A prospective "renal cancer" database was queried for cT<3-cN0-cM0 and pT1a-pT3a-pNx cc-RCC. Out of 1650 cases treated between 2001 and 2013, 921 were cc-RCC and 666 met inclusion criteria, 232 of which treated with minimally invasive RN and 434 with MIPN. A 1:1 propensity score-matched (PSM) analysis was employed to minimize the selection bias of non-random assignment of patients to PN as opposed to RN. Kaplan--Meier method was used to compare the oncologic outcomes of the PSM cohorts. Survival rates were computed at 2, 5, and 10 years after surgery, and the log-rank test was applied to assess statistical significance between the two PSM groups. Results RN tumors were significantly larger (p < 0.001), with higher pT stages (p < 0.001), higher Fuhrman grades (p = 0.002) and a more frequent sarcomatoid differentiation (p = 0.04). After applying the PSM analysis, the two cohorts of 155 RN and 155 PN cases did not differ for all clinical and pathologic covariates (all p a[yen] 0.32). PN and RN cohorts displayed comparable 5-year metastasis-free survival (88.9 vs 89.9 %, p = 0.811), local recurrence-free survival (94.2 vs 95.9 %, p = 0.283), overall survival (94.5 vs 96.8 %, p = 0.419) and cancer-specific survival (96 vs 98.6 %, p = 0.907) rates. Conclusions PN and RN for patients with cc-RCC larger than 7 cm provided equivalent oncologic outcomes. Safety and reproducibility of our findings should be further investigated in larger multicentric cohorts. Author Affiliation: (1) Department of Urology, "Regina Elena" National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy (2) Department of Urology, "Campus Biomedico" University, Rome, Italy (3) Department of Pathology, "Regina Elena" National Cancer Institute, Rome, Italy Article History: Registration Date: 11/08/2016 Received Date: 10/06/2016 Accepted Date: 11/08/2016 Online Date: 30/08/2016
  • Fa parte di: World Journal of Urology, 2017, Vol.35(5), pp.789-794
  • Soggetti: Minimally invasive ; Outcomes ; Partial nephrectomy ; Propensity score matching ; Radical nephrectomy ; Renal cell carcinoma
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 0724-4983 ; E-ISSN: 1433-8726 ; DOI: 10.1007/s00345-016-1923-2

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