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Synthesis of carbocyclic NAD + containing a methylenebisphosphonate linkage for the investigation of ADP-ribosyl cyclase

Hutchinson, Edward J. ; Taylor, Brian F. ; Blackburn, G. Michael

Chemical Communications, 1996, Issue.24, pp.2765-2766 [Rivista Peer Reviewed]

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  • Titolo:
    Synthesis of carbocyclic NAD + containing a methylenebisphosphonate linkage for the investigation of ADP-ribosyl cyclase
  • Autore: Hutchinson, Edward J. ; Taylor, Brian F. ; Blackburn, G. Michael
  • Note di contenuto: A stereospecific synthesis of carbocyclic NAD + incorporating a methylenebisphosphonatelinkage in place of the natural pyrophosphate gives an analogue 4 of the natural coenzyme NAD + 3a designed to act as an inhibitor of ADP-ribosyl cyclase and to resist non-specific phosphatase degradation.
  • Fa parte di: Chemical Communications, 1996, Issue.24, pp.2765-2766
  • Tipo: Articolo
  • Identificativo: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/CC9960002765
  • Fonte: Royal Society of Chemistry

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