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Age- and Sex-Associated Plasma Proteomic Changes in Growth Hormone Receptor Gene–Disrupted Mice

Ding, Juan ; Berryman, Darlene E ; Jara, Adam ; Kopchick, John J

Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2012, Vol. 67(8), pp.830-840 [Rivista Peer Reviewed]

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  • Titolo:
    Age- and Sex-Associated Plasma Proteomic Changes in Growth Hormone Receptor Gene–Disrupted Mice
  • Autore: Ding, Juan ; Berryman, Darlene E ; Jara, Adam ; Kopchick, John J
  • Note di contenuto: Growth hormone receptor gene–disrupted (GHR−/−) mice are dwarf, insulin sensitive, and long lived despite being obese. In order to identify characteristics associated with their increased longevity, we studied age-related plasma proteomic changes in these mice. Male and female GHR−/− mice and their littermate controls were followed longitudinally at 8, 16, and 24 months of ages for plasma proteomic analysis. Relative to control littermates, GHR−/− mice had increased levels of apolipoprotein A-4 and retinol-binding protein-4 and decreased levels of apolipoprotein E, haptoglobin, and mannose-binding protein-C. Female GHR−/− mice showed decreased inflammatory cytokines including interleukin-1β and monocyte chemotactic protein-1. Additionally, sex differences were found in specific isoforms of apolipoprotein E, RBP-4, haptoglobin, albumin, and hemoglobin subunit beta. In conclusion, we find plasma proteomic changes in GHR−/− mice that favor a longer life span as well as sex differences indicative of an improved health span in female mice.
  • Fa parte di: Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2012, Vol. 67(8), pp.830-840
  • Soggetti: Growth Hormone Receptor ; Plasma ; Proteomics ; Sex ; Aging
  • Tipo: Articolo
  • Identificativo: ISSN: 1079-5006 ; E-ISSN: 1758-535X ; DOI: 10.1093/gerona/glr212

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