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Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue

Swindell, William R ; List, Edward O ; Berryman, Darlene E ; Kopchick, John J

Aging, 29 April 2018, Vol.10(4), pp.701-746 [Rivista Peer Reviewed]

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  • Titolo:
    Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue
  • Autore: Swindell, William R ; List, Edward O ; Berryman, Darlene E ; Kopchick, John J
  • Note di contenuto: Caloric restriction (CR) has been extensively studied in rodents as an intervention to improve lifespan and healthspan. However, effects of CR can be strain- and species-specific. This study used publically available microarray data to analyze expression responses to CR in males from 7 mouse strains (C57BL/6J, BALB/c, C3H, 129, CBA, DBA, B6C3F1) and 4 tissues (epididymal white adipose tissue (eWAT), muscle, heart, cortex). In each tissue, the largest number of strain-specific CR responses was identified with respect to the C57BL/6 strain. In heart and cortex, CR responses in C57BL/6 mice were negatively correlated with responses in other strains. Strain-specific CR responses involved genes associated with olfactory receptors (, ) and insulin/IGF-1 signaling (, ). In each strain, CR responses in eWAT were negatively correlated with those in human subcutaneous WAT (scWAT). In human scWAT, CR increased expression of genes associated with stem cell maintenance and vascularization. However,...
  • Fa parte di: Aging, 29 April 2018, Vol.10(4), pp.701-746
  • Soggetti: Adipose ; Aging ; Dietary Restriction ; Insulin ; Insulin-Like Growth Factor ; Longevity ; Microarray ; Olfactory Receptor ; Caloric Restriction ; Species Specificity ; Transcriptome ; Adipose Tissue, White -- Metabolism
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: E-ISSN: 1945-4589 ; PMID: 29708498 Version:1 ; DOI: 10.18632/aging.101424

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