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Oncological outcomes of minimally invasive partial versus minimally invasive radical nephrectomy for cT1-2/N0/M0 clear cell renal cell carcinoma: a propensity score-matched analysis

Simone, Giuseppe ; Tuderti, Gabriele ; Anceschi, Umberto ; Papalia, Rocco ; Ferriero, Mariaconsiglia ; Misuraca, Leonardo ; Minisola, Francesco ; Mastroianni, Riccardo ; Costantini, Manuela ; Guaglianone, Salvatore ; Sentinelli, Steno ; Gallucci, Michele

World journal of urology, May 2017, Vol.35(5), pp.789-794 [Rivista Peer Reviewed]

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  • Titolo:
    Oncological outcomes of minimally invasive partial versus minimally invasive radical nephrectomy for cT1-2/N0/M0 clear cell renal cell carcinoma: a propensity score-matched analysis
  • Autore: Simone, Giuseppe ; Tuderti, Gabriele ; Anceschi, Umberto ; Papalia, Rocco ; Ferriero, Mariaconsiglia ; Misuraca, Leonardo ; Minisola, Francesco ; Mastroianni, Riccardo ; Costantini, Manuela ; Guaglianone, Salvatore ; Sentinelli, Steno ; Gallucci, Michele
  • Note di contenuto: To compare the oncologic outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for cT1-2/N0 renal tumors and pathologically confirmed pT1-pT3a-pNx clear cell (cc)-renal cell carcinoma (RCC). Few studies compared the oncologic outcomes of PN and RN for renal tumors >7 cm. A prospective "renal cancer" database was queried for cT<3-cN0-cM0 and pT1a-pT3a-pNx cc-RCC. Out of 1650 cases treated between 2001 and 2013, 921 were cc-RCC and 666 met inclusion criteria, 232 of which treated with minimally invasive RN and 434 with MIPN. A 1:1 propensity score-matched (PSM) analysis was employed to minimize the selection bias of non-random assignment of patients to PN as opposed to RN. Kaplan-Meier method was used to compare the oncologic outcomes of the PSM cohorts. Survival rates were computed at 2, 5, and 10 years after surgery, and the log-rank test was applied to assess statistical significance between the two PSM groups. RN tumors were significantly larger (p < 0.001), with higher pT stages (p < 0.001), higher Fuhrman grades (p = 0.002) and a more frequent sarcomatoid differentiation (p = 0.04). After applying the PSM analysis, the two cohorts of 155 RN and 155 PN cases did not differ for all clinical and pathologic covariates (all p ≥ 0.32). PN and RN cohorts displayed comparable 5-year metastasis-free survival (88.9 vs 89.9 %, p = 0.811), local recurrence-free survival (94.2 vs 95.9 %, p = 0.283), overall survival (94.5 vs 96.8 %, p = 0.419) and cancer-specific survival (96 vs 98.6 %, p = 0.907) rates.
  • Fa parte di: World journal of urology, May 2017, Vol.35(5), pp.789-794
  • Soggetti: Minimally Invasive ; Outcomes ; Partial Nephrectomy ; Propensity Score Matching ; Radical Nephrectomy ; Renal Cell Carcinoma ; Carcinoma, Renal Cell -- Surgery ; Kidney Neoplasms -- Surgery ; Minimally Invasive Surgical Procedures -- Methods ; Nephrectomy -- Methods
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: E-ISSN: 1433-8726 ; PMID: 27578234 Version:1 ; DOI: 10.1007/s00345-016-1923-2
  • Fonte: MEDLINE/PubMed (U.S. National Library of Medicine)

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