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Method to Biomonitor the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo4,5-bpyridine in Dyed Hair by Ultra-Performance Liquid Chromatography-Orbitrap High Resolution Multistage Mass Spectrometry

Guo, Jingshu ; Yonemori, Kim ; Le Marchand, Loïc ; Turesky, Robert J

Analytical chemistry, 16 June 2015, Vol.87(12), pp.5872-7 [Rivista Peer Reviewed]

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  • Titolo:
    Method to Biomonitor the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo4,5-bpyridine in Dyed Hair by Ultra-Performance Liquid Chromatography-Orbitrap High Resolution Multistage Mass Spectrometry
  • Autore: Guo, Jingshu ; Yonemori, Kim ; Le Marchand, Loïc ; Turesky, Robert J
  • Note di contenuto: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogenic heterocyclic aromatic amine formed in cooked meat. The use of naturally colored hair containing PhIP can serve as a long-term biomarker of exposure to this carcinogen. However, the measurement of PhIP in dyed hair, a cosmetic treatment commonly used by the adult population, is challenging because the dye process introduces into the hair matrix a complex mixture of chemicals that interferes with the measurement of PhIP. The high-resolution scanning features of the Orbitrap Fusion mass spectrometer were employed to biomonitor PhIP in dyed hair. Because of the complexity of chemicals in the hair dye, the consecutive reaction monitoring of PhIP at the MS(3) scan stage was employed to selectively remove the isobaric interferences. The limit of quantification (LOQ) of PhIP was 84 parts-per-trillion (ppt) employing 50 mg of hair. Calibration curves were generated in dyed hair matrixes and showed good linearity (40-1000 pg...
  • Fa parte di: Analytical chemistry, 16 June 2015, Vol.87(12), pp.5872-7
  • Soggetti: Cooking ; Carcinogens -- Analysis ; Colorectal Neoplasms -- Chemistry ; Hair -- Chemistry ; Hair Dyes -- Chemistry ; Imidazoles -- Analysis ; Meat -- Analysis
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: E-ISSN: 1520-6882 ; PMID: 25969997 Version:1 ; DOI: 10.1021/acs.analchem.5b01129

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