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Interaction of the carbon monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of carbon monoxide binding by integrating cavity dual-beam spectrophotometry

Rana, Namrata ; Mclean, Samantha ; Mann, Brian E ; Poole, Robert K

Microbiology (Reading, England), December 2014, Vol.160(Pt 12), pp.2771-2779 [Rivista Peer Reviewed]

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  • Titolo:
    Interaction of the carbon monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of carbon monoxide binding by integrating cavity dual-beam spectrophotometry
  • Autore: Rana, Namrata ; Mclean, Samantha ; Mann, Brian E ; Poole, Robert K
  • Note di contenuto: Carbon monoxide (CO) is a toxic gas that binds to haems, but also plays critical signalling and cytoprotective roles in mammalian systems; despite problems associated with systemic delivery by inhalation of the gas, it may be employed therapeutically. CO delivered to cells and tissues by CO-releasing molecules (CO-RMs) has beneficial and toxic effects not mimicked by CO gas; CO-RMs are also attractive candidates as novel antimicrobial agents. Salmonella enterica serovar Typhimurium is an enteropathogen causing gastroenteritis in humans. Recent studies have implicated haem oxygenase-1 (HO-1), the protein that catalyses the degradation of haem into biliverdin, free iron and CO, in the host immune response to Salmonella infection. In several studies, CO administration via CO-RMs elicited many of the protective roles of HO-1 induction and so we investigated the effects of a well-characterized water-soluble CO-RM, Ru(CO)3Cl(glycinate) (CORM-3), on Salmonella. CORM-3 exhibits toxic effects at...
  • Fa parte di: Microbiology (Reading, England), December 2014, Vol.160(Pt 12), pp.2771-2779
  • Soggetti: Anti-Bacterial Agents -- Metabolism ; Carbon Monoxide -- Metabolism ; Organometallic Compounds -- Metabolism ; Salmonella Typhimurium -- Drug Effects
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: E-ISSN: 1465-2080 ; PMID: 25085864 Version:1 ; DOI: 10.1099/mic.0.081042-0
  • Fonte: MEDLINE/PubMed (U.S. National Library of Medicine)

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