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Synovial sarcoma of children and adolescents: the prognostic role of axial sites

Ferrari, Andrea ; Bisogno, Gianni ; Alaggio, Rita ; Cecchetto, Giovanni ; Collini, Paola ; Rosolen, Angelo ; Meazza, Cristina ; Indolfi, Paolo ; Garaventa, Alberto ; De Sio, Luigi ; D'Angelo, Paolo ; Tamaro, Paolo ; Casanova, Michela ; Carli, Modesto

European journal of cancer (Oxford, England : 1990), June 2008, Vol.44(9), pp.1202-9 [Rivista Peer Reviewed]

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  • Titolo:
    Synovial sarcoma of children and adolescents: the prognostic role of axial sites
  • Autore: Ferrari, Andrea ; Bisogno, Gianni ; Alaggio, Rita ; Cecchetto, Giovanni ; Collini, Paola ; Rosolen, Angelo ; Meazza, Cristina ; Indolfi, Paolo ; Garaventa, Alberto ; De Sio, Luigi ; D'Angelo, Paolo ; Tamaro, Paolo ; Casanova, Michela ; Carli, Modesto
  • Note di contenuto: The outcome of patients with non-extremity synovial sarcoma (SS) is generally worse than that of patients with limb tumours. The present study analysed a series of 115 consecutive SS patients treated in Italian paediatric protocols (period 1979-2005), mainly focusing on the 30 cases arising from 'axial' sites (16 head-neck, 8 trunk, 4 lung-pleura and 2 retroperitoneum). Initial gross resection was achieved in 40% of axial cases and in 80% of limb SS (p<0.0001). Five-year EFS and overall survival (OS) were, respectively, 43.3% and 55.1% for axial SS, and 69.6% (p=0.0068) and 84.0% (p=0.0004) for extremity SS. Local progression/recurrence was the cause of treatment failure in 75% of relapsing patients axial disease. Our findings emphasise that children and adolescents with SS originating at non-extremity locations have a worse prognosis than those with limb SS. Tumour site should be considered when defining a risk-adapted treatment strategy for SS.
  • Fa parte di: European journal of cancer (Oxford, England : 1990), June 2008, Vol.44(9), pp.1202-9
  • Soggetti: Sarcoma, Synovial -- Therapy
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 0959-8049 ; PMID: 18440800 Version:1 ; DOI: 10.1016/j.ejca.2008.03.016
  • Fonte: MEDLINE/PubMed (U.S. National Library of Medicine)

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