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Direct integration of Hox and segmentation gene inputs during Drosophila development

Gebelein, Brian ; Mckay, Daniel J ; Mann, Richard S

Nature, 07 October 2004, Vol.431(7009), pp.653-9 [Rivista Peer Reviewed]

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  • Titolo:
    Direct integration of Hox and segmentation gene inputs during Drosophila development
  • Autore: Gebelein, Brian ; Mckay, Daniel J ; Mann, Richard S
  • Note di contenuto: During Drosophila embryogenesis, segments, each with an anterior and posterior compartment, are generated by the segmentation genes while the Hox genes provide each segment with a unique identity. These two processes have been thought to occur independently. Here we show that abdominal Hox proteins work directly with two different segmentation proteins, Sloppy paired and Engrailed, to repress the Hox target gene Distalless in anterior and posterior compartments, respectively. These results suggest that segmentation proteins can function as Hox cofactors and reveal a previously unanticipated use of compartments for gene regulation by Hox proteins. Our results suggest that these two classes of proteins may collaborate to directly control gene expression at many downstream target genes.
  • Fa parte di: Nature, 07 October 2004, Vol.431(7009), pp.653-9
  • Soggetti: Gene Expression Regulation, Developmental ; Drosophila Proteins -- Metabolism ; Drosophila Melanogaster -- Embryology ; Genes, Insect -- Genetics ; Homeodomain Proteins -- Genetics ; Transcription Factors -- Genetics
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: E-ISSN: 1476-4687 ; PMID: 15470419 Version:1

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