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Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue

Hjortebjerg, Rikke ; Berryman, Darlene E ; Comisford, Ross ; List, Edward O ; Oxvig, Claus ; Bjerre, Mette ; Frystyk, Jan ; Kopchick, John J

Growth Hormone & IGF Research, April 2018, Vol.39, pp.54-61 [Rivista Peer Reviewed]

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  • Titolo:
    Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue
  • Autore: Hjortebjerg, Rikke ; Berryman, Darlene E ; Comisford, Ross ; List, Edward O ; Oxvig, Claus ; Bjerre, Mette ; Frystyk, Jan ; Kopchick, John J
  • Note di contenuto: Pregnancy-associated plasma protein-A (PAPP-A) stimulates insulin-like growth factor (IGF)-I action through proteolytic cleavage of IGF binding protein-4 (IGFBP-4). Recently, stanniocalcin-2 (STC2) was discovered as an inhibitor of PAPP-A. Most members of the IGF system are expressed in adipose tissue (AT), but there is a relative paucity of information on the distribution of IGFBP-4, PAPP-A, and STC2 in different AT depots. Since IGF-I expression in AT is highly GH-dependent, we used bovine GH transgenic (bGH) and GH receptor knockout (GHR−/−) mice to investigate AT depot-specific expression patterns of IGFBP-4, PAPP-A, and STC2, and whether the regulation is GH-dependent. Seven-month-old male bGH, GHR−/− and wild type (WT) control mice were used. Body composition was determined, and subcutaneous, epididymal, retroperitoneal, mesenteric and brown adipose tissue (BAT) depots were collected. RNA expression of Igfbp4, Pappa, and Stc2 was assessed by reverse transcription...
  • Fa parte di: Growth Hormone & IGF Research, April 2018, Vol.39, pp.54-61
  • Soggetti: Adipose Tissue ; Insulin-Like Growth Factor Binding Protein-4 ; Pregnancy-Associated Plasma Protein-A ; Stanniocalcin-2 ; Anova ; At ; Bat ; Bgh ; Cdna ; Cv ; Epi ; Gh ; Ghr ; Ghr−/− ; IGF-I ; IGF-IR ; Igfbp ; IR
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 1096-6374 ; E-ISSN: 1532-2238 ; DOI: 10.1016/j.ghir.2018.01.001

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