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Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice

Brooks, Nicole E ; Hjortebjerg, Rikke ; Henry, Brooke E ; List, Edward O ; Kopchick, John J ; Berryman, Darlene E

Growth Hormone & IGF Research, October 2016, Vol.30-31, pp.22-30 [Rivista Peer Reviewed]

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  • Titolo:
    Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice
  • Autore: Brooks, Nicole E ; Hjortebjerg, Rikke ; Henry, Brooke E ; List, Edward O ; Kopchick, John J ; Berryman, Darlene E
  • Note di contenuto: Although growth hormone (GH) and fibroblast growth factor 21 (FGF21) have a reported relationship, FGF21 and its receptor, fibroblast growth factor receptor 1 (FGFR1) and cofactor β-Klotho (KLB), have not been analyzed in chronic states of altered GH action. The objective of this study was to quantify circulating FGF21 and tissue specific expression of Fgf21, Fgfr1, and Klb in mice with modified GH action. Based on previous studies, we hypothesized that bovine GH transgenic (bGH) mice will be FGF21 resistant and GH receptor knockout (GHR−/−) mice will have normal FGF21 action. Seven-month-old male bGH mice (n=9) and wild type (WT) controls (n=10), and GHR−/− mice (n=8) and WT controls (n=8) were used for all measurements. Body composition was determined before dissection, and tissue weights were measured at the time of dissection. Serum FGF21 levels were evaluated by ELISA. Expression of Fgf21, Fgfr1, and Klb mRNA in white adipose tissue (AT), brown AT, and...
  • Fa parte di: Growth Hormone & IGF Research, October 2016, Vol.30-31, pp.22-30
  • Soggetti: Fibroblast Growth Factor 21 ; Fgf21 ; Fibroblast Growth Factor Receptor 1 ; Fgfr1 ; Β-Klotho ; Klb ; Bgh Mice ; Ghr −/− Mice ; Fibroblast Growth Factor 21 ; Fgf21 ; Fibroblast Growth Factor Receptor 1 ; Fgfr1 ; Β-Klotho ; Klb ; Bgh Mice ; Ghr−/− Mice
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 1096-6374 ; E-ISSN: 1532-2238 ; DOI: 10.1016/j.ghir.2016.08.003

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