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Cytochrome bd-I in Escherichia coli is less sensitive than cytochromes bd-II or bo′' to inhibition by the carbon monoxide-releasing molecule, CORM-3

Jesse, Helen E ; Nye, Tacita L ; Mclean, Samantha ; Green, Jeffrey ; Mann, Brian E ; Poole, Robert K

BBA - Proteins and Proteomics, September 2013, Vol.1834(9), pp.1693-1703 [Rivista Peer Reviewed]

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  • Titolo:
    Cytochrome bd-I in Escherichia coli is less sensitive than cytochromes bd-II or bo′' to inhibition by the carbon monoxide-releasing molecule, CORM-3
  • Autore: Jesse, Helen E ; Nye, Tacita L ; Mclean, Samantha ; Green, Jeffrey ; Mann, Brian E ; Poole, Robert K
  • Note di contenuto: Background: CO-releasing molecules (CO-RMs) are potential therapeutic agents, able to deliver CO – a critical gasotransmitter – in biological environments. CO-RMs are also effective antimicrobial agents; although the mechanisms of action are poorly defined, haem-containing terminal oxidases are primary targets. Nevertheless, it is clear from several studies that the effects of CO-RMs on biological systems are frequently not adequately explained by the release of CO: CO-RMs are generally more potent inhibitors than is CO gas and other effects of the molecules are evident. Methods: Because sensitivity to CO-RMs cannot be predicted by sensitivity to CO gas, we assess the differential susceptibilities of strains, each expressing only one of the three terminal oxidases of E. coli — cytochrome bd-I, cytochrome bd-II and cytochrome bo′, to inhibition by CORM-3. We present the first sensitive measurement of the oxygen affinity of cytochrome bd-II (Km 0.24μM) employing globin deoxygenation....
  • Fa parte di: BBA - Proteins and Proteomics, September 2013, Vol.1834(9), pp.1693-1703
  • Soggetti: Corm-3 ; Corm-2 ; Cytochrome ; Escherichia Coli ; Respiratory Oxidase ; N-Acetylcysteine ; CO-RM ; Corm-2 ; Corm-3 ; Dcfh-Da ; Edta ; Egta ; Ho-1 ; Icorm-3 ; Icp-MS ; Kd ; Kla ; Km ; Lb ; Micorm-3
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 1570-9639 ; E-ISSN: 1878-1454 ; DOI: 10.1016/j.bbapap.2013.04.019

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