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2,4-dichlorophenoxyacetic acid (2,4-D) and risk of non-Hodgkin lymphoma: a meta-analysis accounting for exposure levels

Smith, Adam M ; Smith, Martyn T ; La Merrill, Michele A ; Liaw, Jane ; Steinmaus, Craig

Annals of Epidemiology, April 2017, Vol.27(4), pp.281-289.e4 [Rivista Peer Reviewed]

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  • Titolo:
    2,4-dichlorophenoxyacetic acid (2,4-D) and risk of non-Hodgkin lymphoma: a meta-analysis accounting for exposure levels
  • Autore: Smith, Adam M ; Smith, Martyn T ; La Merrill, Michele A ; Liaw, Jane ; Steinmaus, Craig
  • Note di contenuto: 2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the most commonly used selective herbicides in the world. A number of epidemiology studies have found an association between 2,4-D exposure and non-Hodgkin lymphoma (NHL) but these results are inconsistent and controversial. A previous meta-analysis found no clear association overall but did not specifically examine high-exposure groups. We conducted a systematic review and meta-analysis of the peer-reviewed epidemiologic studies of the associations between 2,4-D and NHL, with a particular focus on high-exposure groups, and evaluations of heterogeneity, dose-response, and bias. A total of 12 observational studies, 11 case-control studies, and one cohort study, were included. The summary relative risk for NHL using study results comparing subjects who were ever versus never exposed to 2,4-D was 1.38 (95% confidence interval (CI), 1.07–1.77). However, in analyses focusing on results from highly exposed groups, the summary relative...
  • Fa parte di: Annals of Epidemiology, April 2017, Vol.27(4), pp.281-289.e4
  • Soggetti: 2,4-D ; Lymphoma ; Non-Hodgkin'S ; Meta-Analysis ; Occupational ; 2,4-D ; Lymphoma ; Non-Hodgkin'S ; Meta-Analysis ; Occupational ; Medicine ; Public Health
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 1047-2797 ; E-ISSN: 1873-2585 ; DOI: 10.1016/j.annepidem.2017.03.003

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