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Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis

Aldo Giudice ; Giovanni D’arena ; Anna Crispo ; Mario Felice Tecce ; Flavia Nocerino ; Maria Grimaldi ; Emanuela Rotondo ; Anna Maria D’ursi ; Mario Scrima ; Massimiliano Galdiero ; Gennaro Ciliberto ; Mario Capunzo ; Gianluigi Franci ; Antonio Barbieri ; Sabrina Bimonte ; Maurizio Montella

Oxidative medicine and cellular longevity, 01 January 2016, Vol.2016 [Rivista Peer Reviewed]

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  • Titolo:
    Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis
  • Autore: Aldo Giudice ; Giovanni D’arena ; Anna Crispo ; Mario Felice Tecce ; Flavia Nocerino ; Maria Grimaldi ; Emanuela Rotondo ; Anna Maria D’ursi ; Mario Scrima ; Massimiliano Galdiero ; Gennaro Ciliberto ; Mario Capunzo ; Gianluigi Franci ; Antonio Barbieri ; Sabrina Bimonte ; Maurizio Montella
  • Note di contenuto: MicroRNAs are short (21–23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. Additionally, recent studies reported that miRNAs can also be encoded by certain single-cell eukaryotes and by viruses. The vast majority of viral miRNAs are encoded by the herpesviruses family. These DNA viruses including Epstein-Barr virus encode their own miRNAs and/or manipulate the expression of cellular miRNAs to facilitate respective infection cycles. Modulation of the control pathways of miRNAs expression is often involved in the promotion of tumorigenesis through a specific cascade of transduction signals. Notably, latent infection with Epstein-Barr virus is considered liable of causing several types of malignancies, including the majority of gastric carcinoma cases detected worldwide. In this...
  • Fa parte di: Oxidative medicine and cellular longevity, 01 January 2016, Vol.2016
  • Soggetti: Biology
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 1942-0900 ; E-ISSN: 1942-0994 ; DOI: 10.1155/2016/6021934
  • Fonte: Directory of Open Access Journals (DOAJ)

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