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New Types of CO-Releasing Molecules (CO-RMs), Based on Iron Dithiocarbamate Complexes and [Fe(CO) 3 I(S 2 COEt)]

Hewison, Lindsay ; Crook, Sian H. ; Mann, Brian E. ; Meijer, Anthony J. H. M. ; Adams, Harry ; Sawle, Philip ; Motterlini, Roberto A.

Organometallics, 08/27/2012, Vol.31(16), pp.5823-5834 [Rivista Peer Reviewed]

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  • Titolo:
    New Types of CO-Releasing Molecules (CO-RMs), Based on Iron Dithiocarbamate Complexes and [Fe(CO) 3 I(S 2 COEt)]
  • Autore: Hewison, Lindsay ; Crook, Sian H. ; Mann, Brian E. ; Meijer, Anthony J. H. M. ; Adams, Harry ; Sawle, Philip ; Motterlini, Roberto A.
  • Note di contenuto: New CO-releasing molecules, [Fe(CO)3X(S2CNR2)] and [Fe(CO)3I(S2COEt)], are reported. [Fe(CO)3X(S2CNR2)] releases the first two carbonyls rapidly to myoglobin (t 1/2 1 min) and the third carbonyl more slowly. In the case of [Fe(CO)3I(S2COEt)], only 0.4 mol of CO are lost. [Fe(CO)3Br(S2CNEt2)] has low toxicity. CO loss is much slower from [Fe(CO)2(S2CNR2)2] (R2 = Me2, Et2, (CH2CH2)2O, (CH2CH2)2, (CH2CH2OH)2; t 1/2 24 h) and is not observed from [Fe(CO)2(S2COEt)2]. The mechanism of CO loss was investigated using Gaussian 09 calculations for [Fe(CO)3Br(S2CNMe2)] and [Fe(CO)2(S2CNMe2)2]. The X-ray structures of [Fe(CO)3Br(S2CNMe2)] and [Fe(CO)3I(S2CNEt2)]2I2 were determined.
  • Fa parte di: Organometallics, 08/27/2012, Vol.31(16), pp.5823-5834
  • Soggetti: Chemistry
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 0276-7333 ; E-ISSN: 1520-6041 ; DOI: http://dx.doi.org/10.1021/om3003637
  • Fonte: American Chemical Society (via CrossRef)

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