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Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung

Bruylant, K ; Crols, R ; Humbel, R.L ; Appel, B ; De Deyn, P.P

Clinical neurology and neurosurgery, 2006, Vol.108 (4), p.415-417 [Rivista Peer Reviewed]

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Titolo:
Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung
Autore: Bruylant, K ; Crols, R ; Humbel, R.L ; Appel, B ; De Deyn, P.P
Editore: Amsterdam: Elsevier B.V
Note di contenuto: Paraneoplastic cerebellar degeneration (PCD) is the most frequent paraneoplastic syndrome affecting the brain. Until now, anti-Tr associated PCD was only seen in patients with Hodgkin's disease. We report a male patient who presented with a progressive ataxia, affecting predominantly the lower limbs and a cerebellar dysarthria. Extensive diagnostic approach initially showed no evidence of tumor. The patient was found to have anti-Tr antibodies in his serum. Fourteen months after onset of symptoms a whole body PET-scan showed a pathological focus at the right hilus of the lungs. A mediastinoscopy was performed and peribronchial node sampling was done. The anatomopathological analysis revealed a non-well differentiated squamous cell carcinoma. This is the first report about the association between an anti-Tr associated PCD and squamous cell carcinoma.
Fa parte di: Clinical neurology and neurosurgery, 2006, Vol.108 (4), p.415-417
Soggetti: Paraneoplastic cerebellar degeneration ; Anti-Purkinje cell antibodies ; Non-well differentiated squamous cell carcinoma ; Anti-Tr antibody ; Biological and medical sciences ; Medical sciences ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Neurosurgery ; Bronchoscopy ; Immunohistochemistry ; Diagnosis, Differential ; Paraneoplastic Cerebellar Degeneration - drug therapy ; Nerve Tissue Proteins - immunology ; Paraneoplastic Cerebellar Degeneration - immunology ; Carcinoma, Squamous Cell - pathology ; Humans ; Lung Neoplasms - pathology ; Male ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - diagnosis ; Magnetic Resonance Imaging ; Lung Neoplasms - immunology ; Antibodies - immunology ; Brain - pathology ; Aged ; Lung Neoplasms - diagnosis ; Viral antibodies ; Physiological aspects ; Antibodies ; Squamous cell carcinoma ; Analysis ; Lung cancer ; Index Medicus
Lingua: Inglese
Tipo: Articolo
Identificativo: ISSN: 0303-8467
EISSN: 1872-6968
DOI: 10.1016/j.clineuro.2005.01.008
PMID: 16644410
CODEN: CNNSBV

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Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung

Bruylant, K ; Crols, R ; Humbel, R.L ; Appel, B ; De Deyn, P.P

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