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Soy protein reduces serum cholesterol by both intrinsic and food displacement mechanisms

Jenkins, David J A ; Mirrahimi, Arash ; Srichaikul, Korbua ; Berryman, Claire E ; Wang, Li ; Carleton, Amanda ; Abdulnour, Shahad ; Sievenpiper, John L ; Kendall, Cyril W C ; Kris-Etherton, Penny M

The Journal of nutrition, December 2010, Vol.140(12), pp.2302S-2311S [Rivista Peer Reviewed]

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  • Titolo:
    Soy protein reduces serum cholesterol by both intrinsic and food displacement mechanisms
  • Autore: Jenkins, David J A ; Mirrahimi, Arash ; Srichaikul, Korbua ; Berryman, Claire E ; Wang, Li ; Carleton, Amanda ; Abdulnour, Shahad ; Sievenpiper, John L ; Kendall, Cyril W C ; Kris-Etherton, Penny M
  • Note di contenuto: The apparently smaller LDL cholesterol (LDL-C)-lowering effect of soy in recent studies has prompted the U.S. FDA to reexamine the heart health claim previously allowed for soy products. We therefore attempted to estimate the intrinsic and extrinsic (displacement) potential of soy in reducing LDL-C to determine whether the heart health claim for soy continues to be justified. The intrinsic effect of soy was derived from a meta-analysis using soy studies (20-133 g/d soy protein) included in the recent AHA Soy Advisory. The extrinsic effect of soy in displacing foods higher in saturated fat and cholesterol was estimated using predictive equations for LDL-C and NHANES III population survey data with the substitution of 13-58 g/d soy protein for animal protein foods. The meta-analysis of the AHA Soy Advisory data gave a mean LDL-C reduction of 0.17 mmol/L (n = 22; P < 0.0001) or 4.3% for soy, which was confirmed in 11 studies reporting balanced macronutrient profiles. The estimated displacement...
  • Fa parte di: The Journal of nutrition, December 2010, Vol.140(12), pp.2302S-2311S
  • Soggetti: Food ; Cholesterol -- Blood ; Soybean Proteins -- Pharmacology
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: E-ISSN: 1541-6100 ; PMID: 20943954 Version:1 ; DOI: 10.3945/jn.110.124958

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