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Perioperative and mid-term oncologic outcomes of robotic assisted radical cystectomy with totally intracorporeal neobladder: Results of a propensity score matched comparison with open cohort from a single-centre series

Simone, Giuseppe ; Tuderti, Gabriele ; Misuraca, Leonardo ; Anceschi, Umberto ; Ferriero, Mariaconsiglia ; Minisola, Francesco ; Guaglianone, Salvatore ; Gallucci, Michele

European journal of surgical oncology, 2018-09, Vol.44 (9), p.1432-1438 [Rivista Peer Reviewed]

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  • Titolo:
    Perioperative and mid-term oncologic outcomes of robotic assisted radical cystectomy with totally intracorporeal neobladder: Results of a propensity score matched comparison with open cohort from a single-centre series
  • Autore: Simone, Giuseppe ; Tuderti, Gabriele ; Misuraca, Leonardo ; Anceschi, Umberto ; Ferriero, Mariaconsiglia ; Minisola, Francesco ; Guaglianone, Salvatore ; Gallucci, Michele
  • Editore: England: Elsevier Ltd
  • Diritti: 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
    Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
    COPYRIGHT 2018 Elsevier B.V.
  • Note di contenuto: In this study, we compared perioperative and oncologic outcomes of patients treated with either open or robot-assisted radical cystectomy and intracorporeal neobladder at a tertiary care center. The institutional prospective bladder cancer database was queried for “cystectomy with curative intent” and “neobladder”. All patients underwent robot-assisted radical cystectomy and intracorporeal neobladder or open radical cystectomy and orthotopic neobladder for high-grade non-muscle invasive bladder cancer or muscle invasive bladder cancer with a follow-up length ≥2 years were included. A 1:1 propensity score matching analysis was used. Kaplan-Meier method was performed to compare oncologic outcomes of selected cohorts. Survival rates were computed at 1,2,3 and 4 years after surgery and the log rank test was applied to assess statistical significance between the matched groups. Overall, 363 patients (299 open and 64 robotic) were included. Open radical cystectomy patients were more frequently male (p = 0.08), with higher pT stages (p = 0.003), lower incidence of urothelial histologies (p = 0.05) and lesser adoption of neoadjuvant chemotherapy (<0.001). After applying the propensity score matching, 64 robot-assisted radical cystectomy patients were matched with 46 open radical cystectomy cases (all p ≥ 0.22). Open cohort showed a higher rate of perioperative overall complications (91.3% vs 42.2%, p 0.001). At Kaplan-Meier analysis robotic and open cohorts displayed comparable disease-free survival (log-rank p = 0.746), cancer-specific survival (p = 0.753) and overall-survival rates (p = 0.909). Robot-assisted radical cystectomy and intracorporeal neobladder provides comparable oncologic outcomes of open radical cystectomy and orthotopic neobladder at intermediate term survival analysis.
  • Fa parte di: European journal of surgical oncology, 2018-09, Vol.44 (9), p.1432-1438
  • Soggetti: Intracorporeal ; Propensity score matching ; Neobladder ; Radical cystectomy ; Robotic ; Outcomes ; Robotic surgery ; Analysis ; Adjuvant treatment ; Cancer ; Index Medicus
  • Lingua: Inglese
  • Tipo: Articolo
  • Identificativo: ISSN: 0748-7983
    EISSN: 1532-2157
    DOI: 10.1016/j.ejso.2018.04.006
    PMID: 29699838
  • Fonte: © ProQuest LLC All rights reserved

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